renal failure — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1410	Torsemide	AC-4464,JDL-464,Torasemide	Na-K-Cl cotransporter
	Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and h...		Na-K-Cl cotransporter
T7714	Temocapil		Tyrosinase
	Temocapril is an inhibitor of tyrosine kinase.		Tyrosinase
T3999	D(+)-Galactosamine hydrochloride	D-Galactosamine HCl	Others
	D(+)-Galactosamine hydrochloride (D-Galactosamine HCl) hepatotoxicity is associated with endotoxin sensitivity and mediated by lymphoreticular cells in mice.		Others
T1615	Irbesartan	SR-47436,BMS-186295	Apoptosis , RAAS
	Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist.		Apoptosis , RAAS
T8150	Nudifloramide	1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide	PARP , Endogenous Metabolite
	Nudifloramide (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide) is one of the end degradation products of nicotinamide-adenine dinucleotide (NAD).		PARP , Endogenous Metabolite
TQ0157	EIPA	L593754,MH 12-43	Sodium Channel , TRP/TRPV Channel
	EIPA (L593754) (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.		Sodium Channel , TRP/TRPV Channel
T6698	Temocapril hydrochloride	CS-622 HCl,Acecol,Temocapril HCl,CS-622	RAAS
	Temocapril hydrochloride (CS-622 HCl), the hydrochloride of Temocapril, is a long-acting ACE inhibitor used for the therapy of hypertension.		RAAS
T1182	Levocarnitine propionate hydrochloride	Propionyl-L-carnitine hydrochloride,L-Propionylcarnitine chloride,ST-261	Histamine Receptor
	Levocarnitine propionate hydrochloride (ST-261) is used for the treatment of the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.		Histamine Receptor
T4238	Glycocyamine	2-Guanidinoacetic acid,Guanidoacetic acid	Others , Endogenous Metabolite
	Glycocyamine (2-Guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird. Glycocyamine is an important marker for renal failure, kidney...		Others , Endogenous Metabolite
TQ0200	Paricalcitol
	Paricalcitol is a vitamin D receptor agonist. It is used for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure.
T22882	JP1302		Adrenergic Receptor
	JP1302 is a selective α2C adrenoceptor antagonist with a Kb value of 16 nM and a Ki of 28 nM for human α2C receptors.JP1302 has antidepressant activity, disrupts the FACT complex and degrades histone H1.JP1302 has been u...		Adrenergic Receptor
T61383	Diaziquone	NSC 182986
	Diaziquone (NSC-182986) is a water-soluble synthetic azacyclic benzoquinone that enhances penetration of the blood-brain barrier, has antitumor activity, and is used in the treatment of extreme renal failure.
T16782	Rolofylline	KW-3902,MK-7418,KF-15372	Adenosine Receptor
	Rolofylline (KW-3902) is a selective adenosine A1 receptor antagonist used in the study of acute congestive heart failure and renal dysfunction, and in the study of neurodegenerative disorders.		Adenosine Receptor
T17284	Zardaverine	BY 290,B 84290	PDE
	Zardaverine (BY 290) is an orally available, selective and potent PDE3/4 inhibitor with bronchodilator activity and anti-hepatocarcinogenic activity.Zardaverine's action in platelets is mediated by PDE III isoenzymes and...		PDE
T0414	D-Mannitol	Mannite,Mannitol,Osmitrol	Apoptosis , Dehydrogenase , Endogenous Metabolite
	D-Mannitol (Mannitol) is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to t...		Apoptosis , Dehydrogenase , Endogenous Metabolite
T4904	1-Methylguanidine hydrochloride		Others , Endogenous Metabolite
	Methylguanidine (MG) is a guanidine compound deriving from protein catabolism. It is also a product of putrefaction. Methylguanidine is a suspected uraemic toxin that accumulates in renal failure, however it also exhibit...		Others , Endogenous Metabolite
T20793	Magnesium Lithospermate B	Monomethyl lithospermate B,Lithospermate B	Others
	Magnesium Lithospermate B is a natural product activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from is...		Others
T28222	5-Hydroxy-1-methylhydantoin	HD-003,HD003,NZ419,NZ-419,HD 003,NZ 419	Bradykinin Receptor
	5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to con...		Bradykinin Receptor
T31594	EA-230	EA 230,NMPF-46,NMPF46,NMPF 46
	Ea-230 is an immunomodulator that may be used in the treatment of renal failure.
T33856	PA 21	PA21
	PA 21 is an iron-based noncalcium phosphate binder that prevents vascular calcification in chronic renal failure rats.